On the promise of glycogen phosphorylase inhibition in acute inflammation

On the promise of glycogen phosphorylase inhibition in acute inflammation

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How glycogen metabolism directly regulates macrophages in the acute inflammatory state is not well understood.In the recent issue of Nature Communications, Ma Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC et al.provide new insight into this process, demonstrating that glycogenolysis-driven pentose phosphate pathway and UDP-glucose-driven P2Y 14 receptor promote an inflammatory phenotype in macrophages.

They show that in vivo blockade of glycogenolysis is sufficient to rescue survival in peritonitis, hepatitis, and sepsis.Their results hold implications Molecular detection, seasonality, epidemiology and effect of Brucella melitensis infection on the hematological profile of cattle breeds for the treatment of acute inflammatory disorders at large.